Prof Henrietta Bowden-Jones OBE, Director of the National Problem Gambling Clinic, said:Ĭlinicians prescribing Aripiprazole must commit to consistently alert patients about these potential risks, both during the initial prescription and follow-up reviews. The UK reports of suspected addictive gambling occurred in patients both with and without a history of problem gambling and most reported that the urges resolved on reducing the dose or stopping treatment with the drug. You should also report them to our Yellow Card scheme. We are highlighting these risks so that you, your family and friends are aware and can flag to your doctor if you are developing urges or cravings that are unusual for you. Please make sure you tell your doctor before starting the medicine if you have a personal history of excessive gambling or any other impulsive behaviours. We are urging all patients to continue to take it and to speak to your doctor if you have any concerns. The number of reports for suspected gambling and other impulsive behaviours associated with aripiprazole are small in comparison to the frequency with which it is prescribed, but the consequences for any patient developing these conditions can be significant.Īripiprazole is an effective and acceptably safe drug for many people. Alison Cave, MHRA Chief Safety Officer, said: Information on these possible side effects have been included in the Patient Information Leaflet and product information since 2012 (gambling) and 2018 (other impulse control disorders). In March 2023, the MHRA asked gambling clinics to report any suspected cases which may account for some of the rise. Thirty-two of these reports were received between 1 January and 31 August this year.

In the last 14 years, the MHRA’s Yellow Card scheme received 69 reports of gambling or gambling disorder where aripiprazole was suspected to be the cause. Stopping aripiprazole without medical advice can be harmful. Patients should continue taking aripiprazole as advised. Patients are advised to tell their doctor if they or their family and friends notice they are having unusual urges or cravings that they cannot resist, including behaviours such as addictive gambling, excessive eating or spending, or an abnormally high sex drive. Aripiprazole is an important medicine for the treatment of schizophrenia and bipolar disorder.

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